#3 All Dogs Can Tolerate Medical Cannabis
While many in the cannabis community believe that the plant may cure a huge variety of ailments, we at right:ratio focus on cancer, arthritis, severe
anxiety and seizures as conditions we believe for which medical cannabis has genuine efficacy.
It is not always true, however, that every dog can safely use medical cannabis. Dogs with liver or heart disease may require a dose reduction or a change in ratio. In cases where the disease is severe enough, we may feel the risk of using cannabis outweighs the benefit and decline treatment.
Another consideration when creating a formula is knowing the breed of the pet. This can be important because, for example, herding breeds are known to possess a genetic mutation in a specific gene called ABCB1/MDR1 gene — which may impact the absorption, distribution and excretion of certain drugs. Because of the mutation, these breeds can be susceptible to severe drug toxicity. The mutation inhibits the transport pump (P-glycoprotein) which may further lower the excretion rate of certain drugs.
The best first step is to identify whether your dog may be among the breeds with the MDR1 mutation before embarking on medical cannabis. Fortunately, the Washington State University Veterinarian School offers low cost saliva tests that many of our customers pets undergo before ordering right:ratio.
Impact on Drug Metabolism
Lastly, certain doses of CBD can inhibit an important enzyme called Cytochrome P450 that assists in the metabolism of specific drugs. We at right ratio carefully review the medications your pet is on (via our intake form) to confirm there are no obvious drug interactions before providing custom medical cannabis for your pet.